46:52Sam Altman describes how conviction, focus, and willingness to adapt helped OpenAI pursue progress in AI despite skepticism and limited resources. He traces the development of OpenAI’s research from early bets on unsupervised learning and reinforcement learning to GPT models, and explains how customer use revealed their commercial potential. He argues that rapid advances in AI, abundant energy, and robotics could enable major gains in science and physical work. For startup founders, his advice is to build with AI, move quickly, and still create products and businesses that deliver real value.

