Deep-tech companies buy equipment and supplies constantly, so giving everyone a card or approving each purchase can slow work and obscure costs. Hodak argues for setting budgets and actively managing procurement, then tracking shared materials and experiment costs. Science built internal software called Helix to connect purchasing, manufacturing, and cost data; one wafer iteration in his example cost $40,000.
Average Is Not Good Enough
Speaker
Max Hodak, CEO of Science, shares lessons on startup infrastructure, hiring, and decision-making at Y Combinator’s Startup School.
Hodak says early hiring should draw on the network around a company’s founding scene, then expand beyond it. At Science, employees vote on applicants, followed by a companywide phone screen, homework, and a full interview. The process spreads review across the team to reduce bottlenecks, and the company uses regular “would you hire this person again?” votes as an ongoing signal about hiring outcomes.
Hodak’s central operating lesson is that iteration speed shapes a company’s chances of success, and infrastructure sets that speed. Purchasing, recruiting, budgeting, and quality systems may sound routine, but weak processes can make a growing organization unwieldy. He also says founders must make their own judgment calls, especially when a high-stakes decision has no clear adviser.
On choosing industry or academia, Hodak says the answer depends on the field: a PhD can make sense where the work remains primarily academic, while a strong company can teach founders how organizations execute. He recommends evidence of concrete achievement and says hands-on work helps people build broad understanding across fields such as neural interfaces. For long-horizon startups, he advises pricing the next value inflection point’s experiments and raising about twice that amount.
Hodak says Science puts company context into Helix so people and AI agents can connect information across purchasing, quality, and manufacturing. He describes AI as a team multiplier, especially for coding and regulatory work such as identifying standards and assembling evidence tables. He argues that internal software can fit a company’s processes more closely than commercial tools, particularly when agents make custom development more accessible.
Takeaways
- Set spending budgets early so employees can make trade-offs without waiting for approval on each purchase.
- Track the cost of experiments and shared materials to make burn, runway, and product pricing visible.
- Design a repeatable hiring process that distributes review and provides feedback after people join.
- Invest in systems that shorten iteration cycles across operations, not only in product development.
- For a long-horizon startup, estimate the cost of the next value inflection point’s experiments and plan funding around it.
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What was claimed 10
- ceo of
“I'm the CEO of a company called Science.”
YouTube Unverified1 source· Talk
- featureScience: Retinal prosthesis uses an implant powered wirelessly by laser projection from glasses
“our main product is a retinal prosthesis”
YouTube Unverified1 source· Talk
- metricScience: One wafer iteration for the described protocol cost $40,000
“for every iteration of a wafer we make, in this case for this protocol, it cost $40,000”
YouTube Unverified1 source· Talk
- featureHelix: Manages company processes and stores lab and manufacturing steps in a database
“every step that happens in the lab [is] in the database”
YouTube Unverified1 source· Talk
- built
“we've built a huge amount of internal software at the company... We call it Helix”
YouTube Unverified1 source· Talk
- usesScience uses
Greenhouse
previously used commercial applicant tracking software“We originally used a commercial applicant tracking system”
YouTube Unverified1 source· Talk
- uses
“The first step in our process, when users apply, is companywide voting.”
YouTube Unverified1 source· Talk
- uses
“Ideally, we'd use entirely AI-resistant homework now.”
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